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Study Information
Study Attribute Value
CEBS Accession Number: 002-02645-0001-0000-0
Chemical Name: Pentaerythritol tetranitrate
CASRN: 78-11-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 896240_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 437 0.416 8.74 26.0 0.000
Test Chemical Pentaerythritol tetranitrate 
160         
 50 1047 567 0.542 11.34 26.0 30.120 
500         
 50 1050 527 0.502 10.54 26.0 20.595 
1600         
 50 1047 525 0.501 10.50 26.0 20.482 
2500         
 50 1050 512 0.488 10.24 26.0 17.162
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 577 0.549 11.54 26.0 31.911
Mitomycin-C 
 0.005     
 10 210 290 1.381 29.00 26.0 231.808
Trend: 1.546        
Probability: 0.061        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 422 0.403 8.44 26.0 0.000
Test Chemical Pentaerythritol tetranitrate 
160         
 50 1053 566 0.538 11.32 26.0 33.359 
500         
 50 1045 543 0.520 10.86 26.0 28.919 
1600         
 50 1050 595 0.567 11.90 26.0 40.592 
2500         
 50 1048 587 0.560 11.74 26.0 38.967
Positive Control Cyclophosphamide 
 0.15      
 50 1046 534 0.511 10.68 26.0 26.661
Cyclophosphamide 
 0.6       
 10 210 282 1.343 28.20 26.0 233.169
Trend: 4.952        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 425 0.405 8.50 26.0 0.000
Test Chemical Pentaerythritol tetranitrate 
160         
 50 1050 528 0.503 10.56 26.0 24.117 
500         
 50 1050 614 0.585 12.28 26.0 44.333 
1600         
 50 1050 551 0.525 11.02 26.0 29.524 
2500         
 50 1050 598 0.570 11.96 26.0 40.572
Positive Control Cyclophosphamide 
 0.1       
 50 1049 576 0.549 11.52 26.0 35.529
Cyclophosphamide 
 0.6       
 10 210 247 1.176 24.70 26.0 190.311
Trend: 4.982        
Probability: 0.000