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Study Information
Study Attribute Value
CEBS Accession Number: 002-02645-0002-0000-1
Chemical Name: Pentaerythritol tetranitrate
CASRN: 78-11-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 896240_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/28/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Pentaerythritol tetranitrate 
1000         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
1600         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2500         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 31 0.155 13.5 10 0.050 5.0 21 0.105 9.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 34.0 6 0.120 12.0 15 0.300 28.0 0 0.000 0.0
Trend: -0.395 -0.640 -0.155  
Probability: 0.654 0.739 0.561  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/28/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Pentaerythritol tetranitrate 
1000         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
1600         
 200 9 0.045 4.0 0 0.000 0.0 9 0.045 4.0 0 0.000 0.0 
2500         
 200 8 0.040 3.5 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 26 0.130 12.5 7 0.035 3.5 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 26 0.520 34.0 6 0.120 12.0 20 0.400 28.0 0 0.000 0.0
Trend: 1.615 0.883 1.632  
Probability: 0.053 0.189 0.051