Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02649-0002-0000-5 |
Chemical Name: | Pentamidine isethionate |
CASRN: | 140-64-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 001715_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Pentamidine isethionate | 47 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
101 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
216 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 19 | 0.760 | 48.0 | 14 | 0.560 | 40.0 | 5 | 0.200 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 1.222 | 0.896 | 0.849 | ||||||||||||
Probability: | 0.111 | 0.185 | 0.198 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 5 | 0.025 | 2.5 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 2.5 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Pentamidine isethionate | 101 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
216 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
465 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 16 | 0.640 | 48.0 | 8 | 0.320 | 32.0 | 8 | 0.320 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 0.202 | -0.734 | 0.723 | ||||||||||||
Probability: | 0.420 | 0.769 | 0.235 |