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Study Information
Study Attribute Value
CEBS Accession Number: 002-02668-0001-0000-5
Chemical Name: Pheniramine maleate
CASRN: 132-20-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 697135_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 05/25/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 428 0.409 8.56 26.0 0.000
Test Chemical Pheniramine maleate 
16         
 50 1048 363 0.346 7.26 26.0 -15.268 
50         
 50 1049 392 0.374 7.84 26.0 -8.586 
160         
 50 1047 437 0.417 8.74 26.0 2.103
Positive Control Mitomycin-C 
 0.005     
 25 522 604 1.157 24.16 26.0 183.054
Trend: 0.622        
Probability: 0.267        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/25/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 482 0.459 9.64 26.0 0.000
Test Chemical Pheniramine maleate 
500         
 50 1048 456 0.435 9.12 26.0 -5.304 
1600         
 50 1046 550 0.526 11.00 26.0 14.435 
5000         
 50 1047 560 0.535 11.20 26.0 16.405
Positive Control Cyclophosphamide 
1         
 25 525 402 0.766 16.08 26.0 66.646
Trend: 3.284        
Probability: 0.001