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Study Information
Study Attribute Value
CEBS Accession Number: 002-02668-0002-0000-6
Chemical Name: Pheniramine maleate
CASRN: 132-20-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 697135_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/25/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Pheniramine maleate 
50         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
160         
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 4.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 26 0.520 40.0 9 0.180 16.0 17 0.340 28.0 0 0.000 0.0
Trend: 1.250 1.013 0.861  
Probability: 0.106 0.156 0.195  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/25/1984    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Pheniramine maleate 
500         
 100 9 0.090 7.0 3 0.030 1.0 6 0.060 6.0 0 0.000 0.0 
1600         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
5000         
 100 12 0.120 11.0 3 0.030 3.0 9 0.090 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 12 0.240 20.0 4 0.080 8.0 8 0.160 12.0 0 0.000 0.0
Trend: 1.462 1.101 1.054  
Probability: 0.072 0.136 0.146