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Study Information
Study Attribute Value
CEBS Accession Number: 002-02670-0001-0000-8
Chemical Name: Phenol
CASRN: 108-95-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 340985_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1   
No Activation  2  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 04/26/1983    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 527 0.505 10.54 25.5 0.000
Test Chemical Phenol 
167         
 50 1035 722 0.698 14.44 33.5 38.193 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 5 104 188 1.808 37.60 25.5 258.108
Trend: 5.671        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/03/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 503 0.482 10.06 25.5 0.000
Test Chemical Phenol 
300         
 50 1026 665 0.648 13.30 32.0 34.526 
350         
 50 1018 716 0.703 14.32 32.0 45.981 
400         
 50 1026 695 0.677 13.90 32.0 40.595 
450         
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1042 584 0.560 11.68 25.5 16.326
Mitomycin-C 
 0.01      
 5 105 180 1.714 36.00 25.5 255.808
Trend: 5.849        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/26/1983    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 480 0.462 9.60 25.5 0.000
Test Chemical Phenol 
1670         
 50 1041 581 0.558 11.62 25.5 20.693 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 5 103 194 1.883 38.80 25.5 307.306
Trend: 3.054        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/03/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 521 0.499 10.42 25.5 0.000
Test Chemical Phenol 
2000         
 50 1037 518 0.500 10.36 25.5 0.191 
2500         
 50 1036 581 0.561 11.62 25.5 12.485 
3000         
 50 1035 633 0.612 12.66 32.0 22.671 
3500         
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Cyclophosphamide 
 0.34      
 50 1039 687 0.661 13.74 25.5 32.623
Cyclophosphamide 
2         
 5 105 153 1.457 30.60 25.5 192.268
Trend: 3.934        
Probability: 0.000