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Study Information
Study Attribute Value
CEBS Accession Number: 002-02670-0002-0000-9
Chemical Name: Phenol
CASRN: 108-95-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 340985_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 05/11/1983    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Phenol 
600         
 100 6 0.060 4.0 1 0.010 1.0 5 0.050 3.0 0 0.000 0.0 
700         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
800         
 100 8 0.080 7.0 1 0.010 1.0 7 0.070 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 25 23 0.920 48.0 15 0.600 44.0 8 0.320 20.0 0 0.000 0.0
Trend: 1.792 0.000 2.007  
Probability: 0.037 0.500 0.022  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/11/1983    Harvest Time: 22.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Phenol 
2000         
 100 137 1.370 18.0 12 0.120 4.0 15 0.150 7.0 110 1.100 11.0 
2500         
 100 106 1.060 14.0 5 0.050 3.0 1 0.010 1.0 100 1.000 10.0 
3000         
 100 21 0.210 17.0 8 0.080 8.0 13 0.130 11.0 0 0.000 0.0 
3500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 27 0.540 34.0 18 0.360 28.0 9 0.180 14.0 0 0.000 0.0
Trend: 2.686 2.234 2.345  
Probability: 0.004 0.013 0.010