Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02670-0012-0000-0
Chemical Name:	Phenol
CASRN:	108-95-2
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	170681_SCE
Study Result:	Negative (Nonstandard Protocol)

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	02/13/86	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Phosphate Buffered Saline	0	4	5.43 ± 0.412
Test Chemical	Phenol	75	4	4.84 ± 0.603
		150	4	4.08 ± 0.333
		300	4	5.18 ± 0.423
Positive Control	Mitomycin-C	0.5	4	9.08 ± 0.669

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	09/04/86	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Phosphate Buffered Saline	0	4	5.53 ± 0.234
Test Chemical	Phenol	75	4	6.23 ± 0.514
		150	4	4.58 ± 0.606
		300	4	5.24 ± 0.247
Positive Control	Mitomycin-C	0.5	4	9.29 ± 0.597

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed