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Study Information
Study Attribute Value
CEBS Accession Number: 002-02670-0012-0000-0
Chemical Name: Phenol
CASRN: 108-95-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 170681_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/13/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.43 ± 0.412
Test Chemical Phenol 
75         
 4 4.84 ± 0.603
  
150         
 4 4.08 ± 0.333
  
300         
 4 5.18 ± 0.423
Positive Control Mitomycin-C 
 0.5       
 4 9.08 ± 0.669


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/04/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.53 ± 0.234
Test Chemical Phenol 
75         
 4 6.23 ± 0.514
  
150         
 4 4.58 ± 0.606
  
300         
 4 5.24 ± 0.247
Positive Control Mitomycin-C 
 0.5       
 4 9.29 ± 0.597


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed