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Study Information
Study Attribute Value
CEBS Accession Number: 002-02671-0001-0000-9
Chemical Name: Phenolphthalein
CASRN: 77-09-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 101813_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/02/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1051 399 0.380 7.98 26.0 1.011
Dimethyl Sulfoxide 
0         
 50 1043 392 0.376 7.84 26.0 0.000
Test Chemical Phenolphthalein 
 0.5       
 50 1047 416 0.397 8.32 26.0 5.717 
1.7       
 50 1050 427 0.407 8.54 26.0 8.202 
5         
 50 1044 379 0.363 7.58 26.0 -3.409 
17         
 50 1047 417 0.398 8.34 26.0 5.971 
50         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 677 0.648 13.54 26.0 72.374
Mitomycin-C 
 0.005     
 10 212 277 1.307 27.70 26.0 247.650
Trend: 0.201        
Probability: 0.421        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/02/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 437 0.417 8.74 26.0 6.655
Dimethyl Sulfoxide 
0         
 50 1042 407 0.391 8.14 26.0 0.000
Test Chemical Phenolphthalein 
1.7       
 50 1047 389 0.372 7.78 26.0 -4.879 
5         
 50 1050 383 0.365 7.66 26.0 -6.614 
17         
 50 1042 361 0.346 7.22 26.0 -11.302 
50         
 50 1042 464 0.445 9.28 31.0 14.005
Positive Control Cyclophosphamide 
 0.125     
 50 1043 556 0.533 11.12 26.0 36.478
Cyclophosphamide 
 0.5       
 10 208 170 0.817 17.00 26.0 109.247
Trend: 1.371        
Probability: 0.085