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Study Information
Study Attribute Value
CEBS Accession Number: 002-02671-0002-0000-0
Chemical Name: Phenolphthalein
CASRN: 77-09-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 101813_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 02/16/1989    Harvest Time: 16.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Phenolphthalein 
11         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
23         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
50         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 67 0.335 25.0 49 0.245 19.5 18 0.090 7.5 0 0.000 0.0
Mitomycin-C 
 0.4       
 50 37 0.740 46.0 25 0.500 40.0 12 0.240 22.0 0 0.000 0.0
Trend: 0.849 1.360 -0.276  
Probability: 0.198 0.087 0.609  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/02/1989    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Phenolphthalein 
30         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
40         
 200 9 0.045 4.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0 
50         
 200 77 0.385 29.0 7 0.035 3.5 70 0.350 27.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 27 0.135 13.0 9 0.045 4.5 18 0.090 9.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 36 0.720 26.0 17 0.340 22.0 9 0.180 10.0 10 0.200 2.0
Trend: 9.359 2.821 9.168  
Probability: 0.000 0.002 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/16/1989    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Phenolphthalein 
11         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
23         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50         
 200 59 0.295 25.0 5 0.025 2.5 54 0.270 22.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 47 0.235 17.0 20 0.100 8.0 27 0.135 10.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 32 0.640 34.0 20 0.400 24.0 12 0.240 18.0 0 0.000 0.0
Trend: 9.157 3.030 8.467  
Probability: 0.000 0.001 0.000