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Study Information
Study Attribute Value
CEBS Accession Number: 002-02675-0001-0000-3
Chemical Name: Phenoxybenzamine hydrochloride
CASRN: 63-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 926929_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/02/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 402 0.383 8.04 26.0 0.000
Test Chemical Phenoxybenzamine hydrochloride 
 0.5       
 50 1049 507 0.483 10.14 26.0 26.240 
1.6       
 50 1051 627 0.597 12.54 26.0 55.822 
5         
 50 1048 857 0.818 17.14 26.0 113.591 
16         
 50 1051 1180 1.123 23.60 26.0 193.253
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 503 0.479 10.06 26.0 25.124
Mitomycin-C 
 0.005     
 10 210 295 1.405 29.50 26.0 266.915
Trend: 22.532        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/21/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 419 0.403 8.38 26.0 0.000
Test Chemical Phenoxybenzamine hydrochloride 
 0.16      
 50 1044 400 0.383 8.00 26.0 -4.992 
 0.5       
 50 1050 769 0.732 15.38 26.0 81.610 
1.6       
 50 1046 513 0.490 10.26 26.0 21.615 
16         
 13 268 301 1.123 23.15 26.0 178.505
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 504 0.481 10.08 26.0 19.253
Mitomycin-C 
 0.005     
 10 210 254 1.210 25.40 26.0 199.927
Trend: 12.668        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/02/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 468 0.446 9.36 26.0 0.000
Test Chemical Phenoxybenzamine hydrochloride 
 0.5       
 50 1050 486 0.463 9.72 26.0 3.747 
1.6       
 50 1052 448 0.426 8.96 26.0 -4.546 
5         
 50 1050 630 0.600 12.60 26.0 34.487 
16         
 50 1049 963 0.918 19.26 26.0 105.769
Positive Control Cyclophosphamide 
 0.1       
 50 1049 563 0.537 11.26 26.0 20.299
Cyclophosphamide 
 0.6       
 10 210 227 1.081 22.70 26.0 142.290
Trend: 14.651        
Probability: 0.000