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Study Information
Study Attribute Value
CEBS Accession Number: 002-02679-0001-0000-7
Chemical Name: Phenylbutazone
CASRN: 50-33-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 534081_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/24/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 428 0.408 8.56 26.0 0.000
Test Chemical Phenylbutazone 
50         
 50 1047 408 0.390 8.16 26.0 -4.491 
160         
 50 1044 440 0.421 8.80 26.0 3.296 
500         
 50 1045 412 0.394 8.24 26.0 -3.370
Positive Control Mitomycin-C 
 0.005     
 25 525 619 1.179 24.76 26.0 188.977
Trend: -0.104        
Probability: 0.541        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/24/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 461 0.439 9.22 26.0 0.000
Test Chemical Phenylbutazone 
160         
 50 1048 423 0.404 8.46 26.0 -8.155 
500         
 50 1047 452 0.432 9.04 26.0 -1.765 
1600         
 50 1042 450 0.432 9.00 26.0 -1.730 
5000         
 50 1051 475 0.452 9.50 28.0 2.841
Positive Control Cyclophosphamide 
1         
 50 1047 826 0.789 16.52 26.0 79.518
Trend: 0.830        
Probability: 0.203