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Study Information
Study Attribute Value
CEBS Accession Number: 002-02679-0002-0000-8
Chemical Name: Phenylbutazone
CASRN: 50-33-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 534081_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 02/24/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Phenylbutazone 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 7 0.070 6.0 0 0.000 0.0 7 0.070 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 15 0.300 22.0 8 0.160 14.0 7 0.140 12.0 0 0.000 0.0
Trend: 1.365 -0.455 1.767  
Probability: 0.086 0.675 0.039  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/24/1983    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Phenylbutazone 
500         
 100 7 0.070 6.0 0 0.000 0.0 7 0.070 6.0 0 0.000 0.0 
1600         
 100 29 0.290 22.0 18 0.180 15.0 11 0.110 11.0 0 0.000 0.0 
5000         
 100 29 0.290 23.0 10 0.100 10.0 19 0.190 17.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 21 0.420 24.0 4 0.080 8.0 17 0.340 18.0 0 0.000 0.0
Trend: 4.517 3.821 3.354  
Probability: 0.000 0.000 0.000