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Study Information
Study Attribute Value
CEBS Accession Number: 002-02680-0001-0000-9
Chemical Name: Phenylephrine hydrochloride
CASRN: 61-76-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 766784_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/18/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1030 456 0.443 9.12 25.5 0.000
Test Chemical Phenylephrine hydrochloride 
1500         
 50 1035 606 0.586 12.12 31.5 32.253 
2000         
 50 1031 570 0.553 11.40 31.5 24.879 
2500         
 50 1031 594 0.576 11.88 31.5 30.137 
3000         
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1020 765 0.750 15.30 25.5 69.408
Mitomycin-C 
 0.01      
 5 104 244 2.346 48.80 25.5 429.943
Trend: 3.495        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/02/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1029 434 0.422 8.68 25.6 0.000
Test Chemical Phenylephrine hydrochloride 
1500         
 50 1032 451 0.437 9.02 25.6 3.615 
2000         
 50 1025 597 0.582 11.94 34.7 38.094 
2500         
 50 1038 625 0.602 12.50 34.7 42.761 
3000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1025 646 0.630 12.92 25.6 49.429
Mitomycin-C 
 0.01      
 5 102 210 2.059 42.00 25.6 388.140
Trend: 7.013        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/18/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1033 511 0.495 10.22 25.5 0.000
Test Chemical Phenylephrine hydrochloride 
8500         
 50 1037 530 0.511 10.60 25.5 3.318 
9000         
 50 1037 557 0.537 11.14 25.5 8.582 
10000         
 50 1029 592 0.575 11.84 25.5 16.302
Positive Control Cyclophosphamide 
 0.4       
 50 1031 673 0.653 13.46 25.5 31.958
Cyclophosphamide 
2         
 5 105 135 1.286 27.00 25.5 159.911
Trend: 2.662        
Probability: 0.004