Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02680-0009-0000-7 |
Chemical Name: | Phenylephrine hydrochloride |
CASRN: | 61-76-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 106595 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 115 | 113 | 118 | 34 | 28 |
118 | 96 | 103 | 29 | ||||
128r | 83 | 118 | 31 | ||||
104 | 91 | 62 | 20 | ||||
Test Chemical | Phenylephrine hydrochloride | 250 | 82 | 64 | 53 | 22 | |
123r | 73 | 59 | 16 | ||||
133r | 89 | 66 | 17 | ||||
500 | 88 | 46 | 56 | 21 | 17 | ||
116 | 46 | 57 | 16 | ||||
90 | 49 | 36 | 13 | ||||
750 | 90 | 39 | 73 | 27 | 27 | ||
117 | 37 | 75 | 21 | ||||
117 | 46 | 110 | 31 | ||||
1000 | 101 | 26 | 66 | 22 | 27 | ||
109 | 30 | 110 | 34 | ||||
107 | 28 | 79 | 25 | ||||
1500 | 76 | 6 | 141 | 62 | 57* | ||
81 | 5 | 109 | 45 | ||||
76 | 7 | 145 | 64 | ||||
1800 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 75 | 38 | 537 | 240 | 233* |
66 | 34 | 484 | 246 | ||||
89 | 48 | 573 | 214 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 91 | 97 | 88 | 32 | 33 |
73 | 90 | 101 | 46 | ||||
94 | 95 | 75 | 27 | ||||
101# | 119 | 84 | 28 | ||||
Test Chemical | Phenylephrine hydrochloride | 125 | 85 | 86 | 88 | 35 | 35 |
83 | 92 | 74 | 30 | ||||
83 | 90 | 99 | 40 | ||||
250 | 77 | 83 | 99 | 43 | 42 | ||
81 | 80 | 103 | 42 | ||||
69 | 68 | 85 | 41 | ||||
500 | 103 | 56 | 72 | 23 | 39 | ||
50 | 50 | 64 | 43 | ||||
62 | 45 | 94 | 50 | ||||
750 | 81 | 45 | 108 | 45 | 35 | ||
97 | 43 | 92 | 32 | ||||
93 | 46 | 83 | 30 | ||||
1000 | 87 | 27 | 125 | 48 | 54* | ||
62 | 20 | 121 | 65 | ||||
84 | 33 | 120 | 48 | ||||
1500 | 71 | 12 | 149 | 70 | 78* | ||
65 | 11 | 162 | 83 | ||||
62 | 13 | 151 | 81 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 65 | 33 | 635 | 324 | 298* |
72 | 42 | 627 | 290 | ||||
63 | 39 | 527 | 281 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination