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Study Information
Study Attribute Value
CEBS Accession Number: 002-02680-0009-0000-7
Chemical Name: Phenylephrine hydrochloride
CASRN: 61-76-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 106595
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Equivocal
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 115 113 118 34 28
    118 96 103 29
    128r 83 118 31
    104 91 62 20
Test Chemical Phenylephrine hydrochloride 
250         
 82 64 53 22
    123r 73 59 16
    133r 89 66 17
  
500         
 88 46 56 21 17
    116 46 57 16
    90 49 36 13
  
750         
 90 39 73 27 27
    117 37 75 21
    117 46 110 31
  
1000         
 101 26 66 22 27
    109 30 110 34
    107 28 79 25
  
1500         
 76 6 141 62 57*
    81 5 109 45
    76 7 145 64
  
1800         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 75 38 537 240 233*
    66 34 484 246
    89 48 573 214

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 91 97 88 32 33
    73 90 101 46
    94 95 75 27
    101# 119 84 28
Test Chemical Phenylephrine hydrochloride 
125         
 85 86 88 35 35
    83 92 74 30
    83 90 99 40
  
250         
 77 83 99 43 42
    81 80 103 42
    69 68 85 41
  
500         
 103 56 72 23 39
    50 50 64 43
    62 45 94 50
  
750         
 81 45 108 45 35
    97 43 92 32
    93 46 83 30
  
1000         
 87 27 125 48 54*
    62 20 121 65
    84 33 120 48
  
1500         
 71 12 149 70 78*
    65 11 162 83
    62 13 151 81
Positive Control Methyl Methane Sulfonate 
5         
 65 33 635 324 298*
    72 42 627 290
    63 39 527 281

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination