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Study Information
Study Attribute Value
CEBS Accession Number: 002-02687-0001-0000-6
Chemical Name: Photodieldrin
CASRN: 13366-73-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 934568_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Questionable 
Induced Rat Liver S9  3_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 09/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 417 0.398 8.34 26.5 0.000
Test Chemical Photodieldrin 
 0.16      
 50 1041 562 0.540 11.24 26.5 35.549 
 0.5       
 50 1051 531 0.505 10.62 26.5 26.853 
1.6       
 50 1036 516 0.498 10.32 26.5 25.055 
5         
 50 1046 493 0.471 9.86 26.5 18.338 
16         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 610 0.581 12.20 26.5 45.865
Mitomycin-C 
 0.01      
 10 210 398 1.895 39.80 26.5 375.855
Trend: 1.542        
Probability: 0.062        

Trial #: 2    Activation: No Activation    Date: 10/08/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 389 0.374 7.78 26.0 0.000
Test Chemical Photodieldrin 
25         
 50 1042 533 0.512 10.66 38.5 36.886 
50         
 50 1039 531 0.511 10.62 38.5 36.767 
75         
 50 1033 539 0.522 10.78 38.5 39.633 
100         
 50 1039 455 0.438 9.10 38.5 17.192
Positive Control Mitomycin-C 
 0.001     
 50 1041 672 0.646 13.44 26.0 72.751
Trend: 2.516        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 387 0.369 7.74 26.0 0.000
Test Chemical Photodieldrin 
16         
 50 1048 445 0.425 8.90 26.0 15.207 
50         
 50 1050 486 0.463 9.72 26.0 25.581 
160         
 100 2098 1104 0.526 11.04 26.0 42.772 
500         
 50 1048 446 0.426 8.92 26.0 15.465 
1000         
 50 1049 460 0.439 9.20 26.0 18.976 
2500         
 50 1048 523 0.499 10.46 26.0 35.400
Positive Control Cyclophosphamide 
 0.3       
 50 1050 612 0.583 12.24 26.0 58.140
Cyclophosphamide 
 0.6       
 10 210 149 0.710 14.90 26.0 92.506
Trend: 3.586        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/08/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 348 0.334 6.96 26.0 0.000
Test Chemical Photodieldrin 
250         
 50 1047 357 0.341 7.14 29.0 2.194 
500         
 50 1048 436 0.416 8.72 29.0 24.690 
1000         
 50 1032 381 0.369 7.62 31.5 10.650 
1500         
 50 1030 380 0.369 7.60 31.5 10.574 
2000         
 50 1040 385 0.370 7.70 31.5 10.951 
2500         
 50 1040 343 0.330 6.86 31.5 -1.152
Positive Control Cyclophosphamide 
 0.3       
 50 1046 486 0.465 9.72 26.0 39.255
Cyclophosphamide 
 0.6       
 10 207 161 0.778 16.10 26.0 133.110
Trend: 0.446        
Probability: 0.328        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 11/27/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 447 0.426 8.94 26.0 0.000
Test Chemical Photodieldrin 
50         
 50 1043 471 0.452 9.42 26.0 6.076 
160         
 50 1044 520 0.498 10.40 32.5 17.000 
500         
 50 1040 534 0.513 10.68 32.5 20.612 
1000         
 50 1032 489 0.474 9.78 32.5 11.304
Positive Control Cyclophosphamide 
 0.3       
 50 1044 652 0.625 13.04 26.0 46.700
Cyclophosphamide 
 0.6       
 10 210 177 0.843 17.70 26.0 97.987
Trend: 2.522        
Probability: 0.006