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Study Information
Study Attribute Value
CEBS Accession Number: 002-02687-0002-0000-7
Chemical Name: Photodieldrin
CASRN: 13366-73-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 934568_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 

Trial #:1   Activation: No Activation    Date: 12/20/1988    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Photodieldrin 
300         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
500         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
1000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 59 0.295 23.5 9 0.045 4.5 50 0.250 20.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 23 0.460 42.0 6 0.120 12.0 17 0.340 32.0 0 0.000 0.0
Trend: 1.132 1.235 0.644  
Probability: 0.129 0.108 0.260  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/20/1984    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Photodieldrin 
750         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1000         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 2.0 0 0.000 0.0 
1500         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
2500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 45 0.450 32.0 23 0.230 20.0 22 0.220 17.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 26 0.520 40.0 17 0.340 30.0 9 0.180 16.0 0 0.000 0.0
Trend: -0.162 0.224 -0.417  
Probability: 0.565 0.411 0.662  


Trial #:2   Activation: No Activation    Date: 09/21/1984    Harvest Time: 22.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Photodieldrin 
500         
 100 5 0.050 4.0 3 0.030 2.0 1 0.010 1.0 1 0.010 1.0 
1000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 16 0.160 11.0 9 0.090 8.0 6 0.060 6.0 1 0.010 1.0
Mitomycin-C 
1         
 50 128 2.560 80.0 43 0.860 54.0 42 0.840 54.0 43 0.860 7.0
Trend: -0.638 0.000 -0.708  
Probability: 0.738 0.500 0.761