U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02688-0001-0000-7
Chemical Name: Phthalamide
CASRN: 88-96-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 869808_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/11/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 464 0.444 9.28 27.0 0.000
Test Chemical Phthalamide 
5         
 50 1042 470 0.451 9.40 27.0 1.488 
16         
 50 1045 500 0.478 10.00 27.0 7.656 
50         
 50 1041 403 0.387 8.06 27.0 -12.896 
160         
 50 1046 490 0.468 9.80 27.0 5.402
Positive Control Mitomycin-C 
 0.001     
 50 1050 692 0.659 13.84 27.0 48.286
Mitomycin-C 
 0.005     
 10 210 315 1.500 31.50 27.0 237.500
Trend: -0.230        
Probability: 0.591        

Trial #: 2    Activation: No Activation    Date: 10/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 440 0.419 8.80 26.5 0.000
Test Chemical Phthalamide 
50         
 50 1050 425 0.405 8.50 26.5 -3.317 
75         
 50 1050 409 0.390 8.18 26.5 -6.957 
100         
 50 1046 437 0.418 8.74 26.5 -0.207 
150         
 50 1048 452 0.431 9.04 26.5 3.021
Positive Control Mitomycin-C 
 0.001     
 50 1049 639 0.609 12.78 26.5 45.504
Mitomycin-C 
 0.005     
 10 210 265 1.262 26.50 26.5 201.423
Trend: 0.567        
Probability: 0.285        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/11/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 374 0.359 7.48 26.5 0.000
Test Chemical Phthalamide 
5         
 50 1040 361 0.347 7.22 26.5 -3.383 
16         
 50 1044 422 0.404 8.44 26.5 12.510 
50         
 50 1044 376 0.360 7.52 26.5 0.246 
160         
 50 1038 447 0.431 8.94 26.5 19.864
Positive Control Cyclophosphamide 
 0.3       
 50 1048 642 0.613 12.84 26.5 70.511
Cyclophosphamide 
 0.6       
 10 206 178 0.864 17.80 26.5 140.509
Trend: 2.579        
Probability: 0.005        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 441 0.420 8.82 26.0 0.000
Test Chemical Phthalamide 
50         
 50 1048 461 0.440 9.22 26.0 4.834 
75         
 50 1047 421 0.402 8.42 26.0 -4.170 
100         
 50 1050 426 0.406 8.52 26.0 -3.309 
150         
 50 1050 431 0.410 8.62 26.0 -2.174
Positive Control Cyclophosphamide 
 0.3       
 50 1046 571 0.546 11.42 26.0 30.097
Cyclophosphamide 
 0.6       
 10 211 172 0.815 17.20 26.0 94.272
Trend: -0.847        
Probability: 0.801