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Study Information
Study Attribute Value
CEBS Accession Number: 002-02692-0001-0000-2
Chemical Name: Picloram
CASRN: 1918-02-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 048749_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/22/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 468 0.445 9.36 25.8 0.000
Test Chemical Picloram 
25         
 50 1046 495 0.473 9.90 25.8 6.275 
83.3       
 50 1040 599 0.576 11.98 25.8 29.345 
250         
 50 1041 868 0.834 17.36 25.8 87.252 
833         
 0 0 0 0.000 0.00 35.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 632 0.602 12.64 25.8 35.171
Mitomycin-C 
 0.01      
 5 106 214 2.019 42.80 25.8 353.383
Trend: 11.937        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 495 0.474 9.90 25.5 0.000
Test Chemical Picloram 
300         
 50 1047 862 0.823 17.24 33.3 73.809 
400         
 50 1044 947 0.907 18.94 33.3 91.496 
500         
 50 1035 1071 1.035 21.42 33.3 118.454 
600         
 0 0 0 0.000 0.00 33.3 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1046 692 0.662 13.84 25.5 39.664
Mitomycin-C 
 0.01      
 5 104 236 2.269 47.20 25.5 379.060
Trend: 14.068        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/22/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 462 0.444 9.24 25.8 0.000
Test Chemical Picloram 
250         
 50 1048 499 0.476 9.98 25.8 7.184 
833         
 50 1042 502 0.482 10.04 25.8 8.449 
2500         
 50 1043 836 0.802 16.72 35.8 80.432
Positive Control Cyclophosphamide 
 0.4       
 50 1041 820 0.788 16.40 25.8 77.319
Cyclophosphamide 
2         
 5 105 291 2.771 58.20 25.8 523.871
Trend: 10.375        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 477 0.458 9.54 25.5 0.000
Test Chemical Picloram 
2000         
 50 1041 662 0.636 13.24 25.5 38.917 
2250         
 50 1047 729 0.696 14.58 33.3 52.100 
2500         
 50 1042 914 0.877 18.28 33.3 91.614
Positive Control Cyclophosphamide 
 0.4       
 50 1047 722 0.690 14.44 25.5 50.640
Cyclophosphamide 
2         
 5 106 253 2.387 50.60 25.5 421.392
Trend: 11.616        
Probability: 0.000