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Study Information
Study Attribute Value
CEBS Accession Number: 002-02692-0002-0000-3
Chemical Name: Picloram
CASRN: 1918-02-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 048749_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/11/1983    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Picloram 
800         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
900         
 100 7 0.070 6.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0 
1000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 11 0.220 20.0 2 0.040 4.0 9 0.180 16.0 0 0.000 0.0
Trend: 0.565 -0.265 1.417  
Probability: 0.286 0.604 0.078  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/11/1983    Harvest Time: 22.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 0 0.000 0.0 2 0.020 2.0 3 0.030 3.0
Test Chemical: Picloram 
2000         
 100 33 0.330 16.0 18 0.180 9.0 12 0.120 8.0 3 0.030 3.0 
2250         
 100 38 0.380 24.0 26 0.260 16.0 8 0.080 6.0 4 0.040 4.0 
2500         
 50 72 1.440 38.0 40 0.800 30.0 22 0.440 26.0 10 0.200 2.0
Positive Control: Cyclophosphamide 
12.5       
 50 16 0.320 28.0 6 0.120 12.0 7 0.140 12.0 3 0.060 6.0
Trend: 5.183 5.618 4.019  
Probability: 0.000 0.000 0.000