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Study Information
Study Attribute Value
CEBS Accession Number: 002-02694-0001-0000-4
Chemical Name: Picric acid
CASRN: 88-89-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 685362_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 444 0.434 8.88 26.0 0.000
Test Chemical Picric acid 
50         
 50 1009 446 0.442 8.92 26.0 1.944 
167         
 50 1025 539 0.526 10.78 33.0 21.278 
500         
 50 1014 616 0.607 12.32 33.0 40.107 
1700         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 562 0.548 11.24 26.0 26.330
Mitomycin-C 
 0.01      
 5 103 208 2.019 41.60 26.0 365.740
Trend: 6.073        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/18/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 455 0.443 9.10 26.0 0.000
Test Chemical Picric acid 
150         
 50 1012 635 0.627 12.70 33.0 41.767 
250         
 50 1024 604 0.590 12.08 33.0 33.266 
500         
 25 515 907 1.761 36.28 33.0 297.907 
750         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 489 0.478 9.78 26.0 7.998
Mitomycin-C 
 0.01      
 5 102 163 1.598 32.60 26.0 261.051
Trend: 24.481        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/27/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1000 379 0.379 7.58 26.0 0.000
Test Chemical Picric acid 
167         
 50 1028 429 0.417 8.58 26.0 10.110 
500         
 50 1014 421 0.415 8.42 26.0 9.548 
1670         
 50 1035 433 0.418 8.66 26.0 10.385 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1032 684 0.663 13.68 26.0 74.879
Cyclophosphamide 
2         
 5 105 281 2.676 56.20 26.0 606.119
Trend: 1.277        
Probability: 0.101