Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02702-0001-0000-4 |
Chemical Name: | Piperonyl butoxide |
CASRN: | 51-03-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 593446_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1040 | 481 | 0.463 | 9.62 | 25.5 | 0.000 |
Test Chemical | Piperonyl butoxide | 4.32 | 50 | 1036 | 479 | 0.462 | 9.58 | 25.5 | -0.031 |
8.62 | 50 | 1035 | 486 | 0.470 | 9.72 | 25.5 | 1.528 | ||
17.3 | 50 | 1034 | 533 | 0.515 | 10.66 | 32.5 | 11.454 | ||
34.5 | 0 | 0 | 0 | 0.000 | 0.00 | 32.5 | N/A | ||
59.4 | 0 | 0 | 0 | 0.000 | 0.00 | 32.5 | N/A | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 521 | 700 | 1.344 | 28.00 | 25.5 | 190.502 |
Trend: | 1.742 | ||||||||
Probability: | 0.041 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1026 | 357 | 0.348 | 7.14 | 25.7 | 0.000 |
Test Chemical | Piperonyl butoxide | 85 | 50 | 1012 | 305 | 0.301 | 6.10 | 25.7 | -13.384 |
125 | 50 | 1018 | 284 | 0.279 | 5.68 | 25.7 | -19.823 | ||
198 | 50 | 1006 | 376 | 0.374 | 7.52 | 31.0 | 7.416 | ||
Positive Control | Cyclophosphamide | 1.5 | 50 | 1025 | 1027 | 1.002 | 20.54 | 25.7 | 187.956 |
Trend: | 0.767 | ||||||||
Probability: | 0.221 |