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Study Information
Study Attribute Value
CEBS Accession Number: 002-02702-0002-0000-5
Chemical Name: Piperonyl butoxide
CASRN: 51-03-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 593446_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/11/1981    Harvest Time: 11.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Piperonyl butoxide 
144         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
248         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
287         
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0 
347         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 22 0.440 34.0 12 0.240 18.0 7 0.140 12.0 3 0.060 3.0
Trend: 1.049 0.225 1.349  
Probability: 0.147 0.411 0.089  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1981    Harvest Time: 11.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 14 0.140 3.0 1 0.010 1.0 3 0.030 0.0 10 0.100 1.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 2.0 1 0.010 1.0 4 0.040 1.0 0 0.000 0.0
Test Chemical: Piperonyl butoxide 
99         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
396         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
496         
 100 7 0.070 6.0 3 0.030 2.0 3 0.030 3.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 50 20 0.400 16.0 7 0.140 10.0 3 0.060 6.0 10 0.200 1.0
Trend: 1.049 0.213 1.209  
Probability: 0.147 0.416 0.113