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Study Information
Study Attribute Value
CEBS Accession Number: 002-02703-0001-0000-5
Chemical Name: Piperonyl sulfoxide
CASRN: 120-62-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616035_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 07/21/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 454 0.434 9.08 25.8 0.000
Test Chemical Piperonyl sulfoxide 
 0.34      
 50 1040 505 0.486 10.10 25.8 11.982 
1.01      
 50 1039 488 0.470 9.76 25.8 8.317 
3.36      
 0 0 0 0.000 0.00 25.8 N/A 
10.09      
 50 1039 479 0.461 9.58 30.8 6.319 
33.63      
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 520 750 1.442 30.00 25.8 232.620
Trend: 0.515        
Probability: 0.303        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/21/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 467 0.447 9.34 25.8 0.000
Test Chemical Piperonyl sulfoxide 
10.1       
 50 1046 484 0.463 9.68 25.8 3.541
Positive Control Cyclophosphamide 
1.5       
 25 525 914 1.741 36.56 25.8 289.571
Trend: 0.000        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/10/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 448 0.429 8.96 25.5 0.000
Test Chemical Piperonyl sulfoxide 
10.1       
 50 1044 506 0.485 10.12 25.5 13.055 
15.1       
 50 1038 455 0.438 9.10 25.5 2.247 
20.2       
 50 1051 539 0.513 10.78 25.5 19.626 
25.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1055 742 0.703 14.84 25.5 64.055
Cyclophosphamide 
2         
 5 104 217 2.087 43.40 25.5 386.704
Trend: 2.038        
Probability: 0.021        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 08/24/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 461 0.442 9.22 25.6 0.000
Test Chemical Piperonyl sulfoxide 
15.1       
 50 1044 484 0.464 9.68 25.6 4.889 
17.2       
 50 1042 484 0.464 9.68 25.6 5.090 
20.2       
 50 1038 548 0.528 10.96 25.6 19.445 
22.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1044 730 0.699 14.60 25.6 58.200
Cyclophosphamide 
2         
 5 104 161 1.548 32.20 25.6 250.248
Trend: 2.772        
Probability: 0.003