Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02706-0009-0000-6
Chemical Name: Polybrominated biphenyl mixture (Firemaster FF-1)
CASRN: 67774-32-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 103512_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/01/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5334
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.75 ± 2.15 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 8 5.50 ± 2.20 0.0046
  
2500         
 8 7.00 ± 1.56 0.0003
  
5000         
 8 2.50 ± 0.73 0.3168
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/02/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6538
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 7.71 ± 2.16 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 8 0.50 ± 0.33 0.7938
  
2500         
 8 0.00 ± 0.00 0.9775
  
5000         
 8 0.75 ± 0.37 0.6479
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/08/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1220
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 36.00 ± 3.25 0.0000
Test Chemical Polybrominated biphenyl mixture (Firemaster FF-1) 
1250         
 7 2.00 ± 0.76 0.0682
  
2500         
 8 1.75 ± 0.80 0.1015
  
5000         
 8 2.00 ± 0.65 0.0645
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed