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Study Information
Study Attribute Value
CEBS Accession Number: 002-02711-0001-0000-4
Chemical Name: Polysorbate 80 (glycol)
CASRN: 9005-65-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 862010_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1049 381 0.363 7.62 26.0 0.000
Test Chemical Polysorbate 80 (glycol) 
16         
 50 1049 357 0.340 7.14 26.0 -6.299 
50         
 50 1048 379 0.362 7.58 26.0 -0.430 
160         
 50 1050 421 0.401 8.42 26.0 10.393 
500         
 32 672 240 0.357 7.50 26.0 -1.669
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 511 0.487 10.22 26.0 34.121
Mitomycin-C 
 0.005     
 10 210 287 1.367 28.70 26.0 276.282
Trend: 1.006        
Probability: 0.157        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1049 368 0.351 7.36 26.0 0.000
Test Chemical Polysorbate 80 (glycol) 
16         
 50 1046 396 0.379 7.92 26.0 7.917 
50         
 50 1046 430 0.411 8.60 26.0 17.183 
160         
 50 1050 427 0.407 8.54 26.0 15.922 
500         
 50 1048 417 0.398 8.34 26.0 13.423
Positive Control Cyclophosphamide 
 0.1       
 50 1049 466 0.444 9.32 26.0 26.630
Cyclophosphamide 
 0.6       
 10 210 228 1.086 22.80 26.0 209.488
Trend: 2.006        
Probability: 0.022