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Study Information
Study Attribute Value
CEBS Accession Number: 002-02711-0002-0000-5
Chemical Name: Polysorbate 80 (glycol)
CASRN: 9005-65-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 862010_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 09/24/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Solvent 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Polysorbate 80 (glycol) 
300         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
500         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 40 0.200 16.0 16 0.080 6.0 24 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 30.0 13 0.260 22.0 4 0.080 8.0 0 0.000 0.0
Trend: -0.395 0.341 -0.585  
Probability: 0.653 0.366 0.721  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/10/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Solvent 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Polysorbate 80 (glycol) 
100         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
300         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 11 0.055 4.0 1 0.005 0.5 10 0.050 3.5 0 0.000 0.0 
750         
 200 12 0.060 5.0 2 0.010 1.0 9 0.045 3.5 1 0.005 1.0 
1000         
 200 33 0.165 13.5 4 0.020 1.5 29 0.145 12.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 23 0.115 10.0 0 0.000 0.0 23 0.115 10.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 27 0.540 28.0 1 0.020 2.0 16 0.320 26.0 10 0.200 1.0
Trend: 5.987 2.463 5.472  
Probability: 0.000 0.007 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/21/1986    Harvest Time: 13.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Solvent 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Polysorbate 80 (glycol) 
160         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
300         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 200 19 0.095 8.0 8 0.040 4.0 11 0.055 4.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 15.0 7 0.035 3.0 28 0.140 12.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 23 0.460 36.0 8 0.160 14.0 15 0.300 26.0 0 0.000 0.0
Trend: 4.073 2.714 3.009  
Probability: 0.000 0.003 0.001