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Study Information
Study Attribute Value
CEBS Accession Number: 002-02733-0001-0000-8
Chemical Name: Probenecid
CASRN: 57-66-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722868_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/05/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 388 0.370 7.76 26.0 0.000
Test Chemical Probenecid 
5         
 50 1048 399 0.381 7.98 26.0 2.835 
16         
 50 1050 445 0.424 8.90 26.0 14.472 
50         
 50 1049 510 0.486 10.20 26.0 31.318 
160         
 50 1047 539 0.515 10.78 26.0 39.050
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 500 0.478 10.00 26.0 28.989
Mitomycin-C 
 0.005     
 10 210 308 1.467 30.80 26.0 296.151
Trend: 6.121        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/04/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 417 0.401 8.34 26.0 0.000
Test Chemical Probenecid 
5         
 50 1036 356 0.344 7.12 26.0 -14.381 
16         
 50 1040 424 0.408 8.48 26.0 1.581 
50         
 50 1035 379 0.366 7.58 26.0 -8.761 
160         
 50 1036 406 0.392 8.12 26.0 -2.356
Positive Control Mitomycin-C 
 0.0E-4    
 50 1042 542 0.520 10.84 26.0 29.602
Mitomycin-C 
 0.005     
 10 207 285 1.377 28.50 26.0 243.047
Trend: 0.063        
Probability: 0.475        

Trial #: 3    Activation: No Activation    Date: 12/13/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 383 0.366 7.66 26.0 0.000
Test Chemical Probenecid 
5         
 50 1045 465 0.445 9.30 26.0 21.526 
16         
 50 1044 458 0.439 9.16 26.0 19.811 
50         
 50 1042 440 0.422 8.80 26.0 15.324 
160         
 50 1043 545 0.523 10.90 26.0 42.707
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 501 0.479 10.02 26.0 30.684
Mitomycin-C 
 0.005     
 10 210 317 1.510 31.70 26.0 312.262
Trend: 4.480        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/05/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 479 0.458 9.58 26.0 0.000
Test Chemical Probenecid 
50         
 50 1047 455 0.435 9.10 26.0 -5.192 
160         
 50 1044 498 0.477 9.96 26.0 4.066 
500         
 50 1048 424 0.405 8.48 26.0 -11.736 
1250         
 50 1046 464 0.444 9.28 26.0 -3.224
Positive Control Cyclophosphamide 
 0.15      
 50 1046 619 0.592 12.38 26.0 29.104
Cyclophosphamide 
 0.6       
 10 210 198 0.943 19.80 26.0 105.696
Trend: -0.945        
Probability: 0.828