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Study Information
Study Attribute Value
CEBS Accession Number: 002-02733-0002-0000-9
Chemical Name: Probenecid
CASRN: 57-66-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722868_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/10/1988    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Probenecid 
500         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
1000         
 200 8 0.040 4.0 0 0.000 0.0 7 0.035 3.5 1 0.005 1.0 
1250         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 18 0.090 8.5 4 0.020 2.0 14 0.070 6.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 30 0.600 46.0 13 0.260 22.0 17 0.340 32.0 0 0.000 0.0
Trend: 1.004 -0.526 1.008  
Probability: 0.158 0.701 0.157  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/10/1988    Harvest Time: 13.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Probenecid 
500         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
1000         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
1250         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 24 0.120 11.5 7 0.035 3.5 17 0.085 8.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 22 0.440 40.0 6 0.120 12.0 16 0.320 32.0 0 0.000 0.0
Trend: 1.052 1.803 -0.419  
Probability: 0.146 0.036 0.662