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Study Information
Study Attribute Value
CEBS Accession Number: 002-02736-0002-0000-2
Chemical Name: Progesterone
CASRN: 57-83-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 303263
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 96# 100 213 74 89
    88 102 253 96
    96# 103 255 89
    82 95 240 98
Test Chemical Progesterone 
27         
 75 54 268 120 123
    70 75 266 127
  
36         
 74 58 189 86 97
    63 68 207 109
  
47         
 61 62 254 139 105
    101 58 218 72
  
63         
 68 42 174 86 77
    82 47 166 68
  
84         
  
112.5       
   
Positive Control Ethyl Methane Sulfonate 
500         
 56# 54 1113 668 677*
    45 37 881 660
    50# 40 1058 702

Nonactivation Trial: 2 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 87 129 211 81 84
    75 123 208 92
    72 91 169 78
    59 56 149 84
Test Chemical Progesterone 
32         
 70 94 258 123 105
    62 82 201 109
    55 64 137 84
  
40         
 63 48 208 110 109
    79 76 187 79
    62 61 255 138
  
50         
 57 31 165 96 105
    82# 65 265 107
    75 62 251 111
  
63         
 64 25 192 100 137*
    58 19 246 142
    55 17 282 170
  
78         
   
   
Positive Control Ethyl Methane Sulfonate 
500         
 52 75 457 294 287*
    63 79 462 246
    56 79 544 323

Induced S9 Trial: 1 Experiment Call:
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 83 89 233 94 92
    97 107 275 95
    96 104 249 87
Test Chemical Progesterone 
36         
 88 120 219 83 94
    81 103 253 104
  
47         
 85 130 188 74 82
    82 100 221 89
  
63         
 86 102 262 102 94
    83 113 212 86
  
84         
 71 77 193 90 80
    84 112 175 69
  
112.5       
 86 91 206 80 79
    71 80 163 77
  
150         
 70 7 229 110 94
    68 12 158 77
  
200         
   
Positive Control 3-Methylcholanthrene 
5         
 69 66 511 247 250*
    82 79 611 248
    72 74 546 253

Induced S9 Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 113 108 321 95 87
    95 92 222 78
    125r 120 297 80
Test Chemical Progesterone 
50         
 64 81 204 107 108
    73 79 204 93
    71 70 264 124
  
63         
 91 90 226 83 93
    80 86 245 103
    135r 150 272 67
  
78         
 88 92 263 100 92
    109 110 265 81
    89 111 252 95
  
98         
 71 68 211 99 97
    92 81 319 115
    99 96 231 78
  
122         
 83 40 238 96 108
    96 32 300 104
    81 25 298 122
  
175         
   
   
Positive Control 3-Methylcholanthrene 
5         
 94 75 638 225 235*
    74 56 541 244

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination