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Study Information
Study Attribute Value
CEBS Accession Number: 002-02739-0001-0000-4
Chemical Name: Propantheline bromide
CASRN: 50-34-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 856934_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1   
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/12/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1034 451 0.436 9.02 25.8 0.000
Test Chemical Propantheline bromide 
1670         
 50 1027 552 0.537 11.04 25.8 23.229 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 516 711 1.378 28.44 25.8 215.910
Trend: 3.297        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/16/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 454 0.434 9.08 25.8 0.000
Test Chemical Propantheline bromide 
2250         
 50 1042 552 0.530 11.04 25.8 22.053 
2750         
 50 1040 721 0.693 14.42 34.5 59.727 
3000         
 50 1034 699 0.676 13.98 34.5 55.752 
3500         
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Mitomycin-C 
 0.005     
 25 520 816 1.569 32.64 25.8 261.545
Trend: 8.795        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/03/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1052 504 0.479 10.08 25.8 0.000
Test Chemical Propantheline bromide 
500         
 50 1043 538 0.516 10.76 25.8 7.667 
1670         
 50 1039 525 0.505 10.50 25.8 5.470 
5000         
 50 1040 505 0.486 10.10 25.8 1.355
Positive Control Cyclophosphamide 
1.5       
 25 518 891 1.720 35.64 25.8 259.032
Trend: 0.105        
Probability: 0.458        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 529 0.506 10.58 25.8 0.000
Test Chemical Propantheline bromide 
4500         
 50 1051 607 0.578 12.14 25.8 14.199 
5000         
 50 1037 538 0.519 10.76 25.8 2.584 
5500         
 50 1049 580 0.553 11.60 25.8 9.327 
6000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 529 1004 1.898 40.16 25.8 275.279
Trend: 0.774        
Probability: 0.219