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Study Information
Study Attribute Value
CEBS Accession Number: 002-02741-0001-0000-7
Chemical Name: Propiolactone
CASRN: 57-57-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 029474_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/29/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 0 0 0 0.000 0.00 27.0 N/A
Negative (Not Specified) 
0         
 50 1046 385 0.368 7.70 27.0 0.000
Test Chemical Propiolactone 
1.1       
 50 1048 704 0.672 14.08 27.0 0.000 
3.8       
 50 1045 1268 1.213 25.36 27.0 0.000 
11         
 50 1048 2734 2.609 54.68 29.0 0.000 
38         
 0 0 0 0.000 0.00 27.0 N/A 
110         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Triethylenemelamine 
 0.02      
 50 1046 2783 2.661 55.66 27.0 0.000
Trend: 35.782        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/29/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 385 0.367 7.70 27.0 0.000
Negative (Not Specified) 
0         
 0 0 0 0.000 0.00 27.0 N/A
Test Chemical Propiolactone 
1.1       
 50 1046 566 0.541 11.32 27.0 0.000 
3.8       
 50 1050 907 0.864 18.14 27.0 0.000 
11         
 50 1043 1991 1.909 39.82 27.0 0.000 
33         
 0 0 0 0.000 0.00 29.0 N/A 
110         
 0 0 0 0.000 0.00 27.0 N/A 
330         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1044 3274 3.136 65.48 27.0 0.000
Trend: 29.316        
Probability: 0.000