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Study Information
Study Attribute Value
CEBS Accession Number: 002-02741-0002-0000-8
Chemical Name: Propiolactone
CASRN: 57-57-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 029474_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/06/1980    Harvest Time: 11.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Propiolactone 
3.6       
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
7.2       
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
14         
 100 18 0.180 16.0 13 0.130 12.0 5 0.050 5.0 0 0.000 0.0 
29         
 50 154 3.080 92.0 82 1.640 82.0 71 1.420 66.0 1 0.020 2.0
Positive Control: Triethylenemelamine 
 0.25      
 100 22 0.220 20.0 11 0.110 11.0 11 0.110 10.0 0 0.000 0.0
Trend: 11.729 11.209 9.682  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/20/1980    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Water 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Propiolactone 
3.6       
 100 3 0.030 2.0 2 0.020 1.0 1 0.010 1.0 0 0.000 0.0 
7.2       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
14         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
29         
 100 22 0.220 21.0 11 0.110 11.0 11 0.110 10.0 0 0.000 0.0 
57         
 100 117 1.170 51.0 45 0.450 30.0 69 0.690 36.0 3 0.030 3.0
Positive Control: Cyclophosphamide 
25         
 100 73 0.730 45.0 28 0.280 24.0 43 0.430 29.0 2 0.020 2.0
Trend: 10.737 7.655 9.178  
Probability: 0.000 0.000 0.000