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Study Information
Study Attribute Value
CEBS Accession Number: 002-02741-0003-0000-9
Chemical Name: Propiolactone
CASRN: 57-57-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 925474_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/04/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 410 0.391 8.20 26.0 0.000
Test Chemical Propiolactone 
 0.002     
 50 1048 389 0.371 7.78 26.0 -5.031 
 0.02      
 50 1048 435 0.415 8.70 26.0 6.199 
 0.2       
 50 1046 425 0.406 8.50 26.0 3.956 
2         
 50 1046 559 0.534 11.18 26.0 36.733 
20         
 50 1046 2191 2.095 43.82 26.0 435.923
Positive Control Triethylenemelamine 
 0.025     
 50 1050 3151 3.001 63.02 26.0 667.805
Trend: 41.536        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/04/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 465 0.443 9.30 26.0 0.000
Test Chemical Propiolactone 
 0.002     
 50 1047 455 0.435 9.10 26.0 -1.964 
 0.02      
 50 1051 418 0.398 8.36 26.0 -10.279 
 0.2       
 50 1049 438 0.418 8.76 26.0 -5.806 
2         
 50 1049 592 0.564 11.84 26.0 27.312 
20         
 50 1049 2046 1.950 40.92 26.0 340.000
Positive Control Cyclophosphamide 
1.5       
 50 1048 1808 1.725 36.16 26.0 289.188
Trend: 36.726        
Probability: 0.000