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Study Information
Study Attribute Value
CEBS Accession Number: 002-02741-0004-0000-0
Chemical Name: Propiolactone
CASRN: 57-57-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 925474_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 09/04/1980    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Propiolactone 
 0.002     
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
 0.02      
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
 0.2       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
2         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
20         
 100 106 1.060 44.0 67 0.670 38.0 39 0.390 22.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 31 0.310 22.0 15 0.150 12.0 16 0.160 14.0 0 0.000 0.0
Trend: 8.438 8.713 5.532  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/04/1980    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Propiolactone 
 0.003     
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
 0.02      
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
 0.2       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
2         
 100 6 0.060 5.0 0 0.000 0.0 6 0.060 5.0 0 0.000 0.0 
20         
 100 39 0.390 26.0 27 0.270 21.0 12 0.120 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 77 0.770 53.0 34 0.340 32.0 43 0.430 32.0 0 0.000 0.0
Trend: 7.067 6.108 4.526  
Probability: 0.000 0.000 0.000