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Study Information
Study Attribute Value
CEBS Accession Number: 002-02742-0001-0000-8
Chemical Name: Propionaldehyde
CASRN: 123-38-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 527837_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 428 0.409 8.56 26.0 0.000
Test Chemical Propionaldehyde 
5         
 50 1047 497 0.475 9.94 26.0 16.121 
16         
 50 1048 889 0.848 17.78 26.0 107.512 
50         
 25 524 866 1.653 34.64 26.0 304.287 
160         
 25 522 1422 2.724 56.88 26.0 566.395
Positive Control Mitomycin-C 
 0.005     
 25 522 604 1.157 24.16 26.0 183.054
Trend: 46.208        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 482 0.459 9.64 26.0 0.000
Test Chemical Propionaldehyde 
50         
 50 1047 639 0.610 12.78 26.0 32.826 
160         
 25 525 552 1.051 22.08 26.0 128.828 
500         
 25 524 1091 2.082 43.64 26.0 353.129
Positive Control Cyclophosphamide 
1         
 25 525 402 0.766 16.08 26.0 66.646
Trend: 31.903        
Probability: 0.000