Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02742-0002-0000-9 |
Chemical Name: | Propionaldehyde |
CASRN: | 123-38-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 527837_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Propionaldehyde | 50 | 100 | 9 | 0.090 | 9.0 | 2 | 0.020 | 2.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 |
160 | 100 | 14 | 0.140 | 14.0 | 4 | 0.040 | 4.0 | 10 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 22 | 0.220 | 21.0 | 8 | 0.080 | 8.0 | 14 | 0.140 | 14.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 26 | 0.520 | 40.0 | 9 | 0.180 | 16.0 | 17 | 0.340 | 28.0 | 0 | 0.000 | 0.0 |
Trend: | 4.096 | 3.161 | 2.886 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.002 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Propionaldehyde | 160 | 100 | 8 | 0.080 | 6.0 | 3 | 0.030 | 3.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 |
500 | 100 | 16 | 0.160 | 14.0 | 4 | 0.040 | 4.0 | 12 | 0.120 | 10.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 17 | 0.170 | 17.0 | 7 | 0.070 | 7.0 | 10 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 12 | 0.240 | 20.0 | 4 | 0.080 | 8.0 | 8 | 0.160 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 3.207 | 2.238 | 2.100 | ||||||||||||
Probability: | 0.001 | 0.013 | 0.018 |