Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02744-0001-0000-0 |
Chemical Name: | Propionitrile |
CASRN: | 107-12-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 522045_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1034 | 432 | 0.418 | 8.64 | 26.5 | 0.000 |
Test Chemical | Propionitrile | 48.5 | 50 | 1041 | 433 | 0.416 | 8.66 | 26.5 | -0.443 |
146 | 50 | 1031 | 429 | 0.416 | 8.58 | 26.5 | -0.405 | ||
485 | 50 | 1027 | 443 | 0.431 | 8.86 | 26.5 | 3.245 | ||
1460 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1024 | 640 | 0.625 | 12.80 | 26.5 | 49.595 |
Mitomycin-C | 0.01 | 10 | 205 | 342 | 1.668 | 34.20 | 26.5 | 299.309 | |
Trend: | 0.459 | ||||||||
Probability: | 0.323 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 427 | 0.407 | 8.54 | 25.5 | 0.000 |
Test Chemical | Propionitrile | 485 | 50 | 1049 | 399 | 0.380 | 7.98 | 25.5 | -6.646 |
1460 | 50 | 1049 | 347 | 0.331 | 6.94 | 25.5 | -18.813 | ||
4850 | 50 | 1049 | 360 | 0.343 | 7.20 | 25.5 | -15.771 | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1046 | 719 | 0.687 | 14.38 | 25.5 | 68.706 |
Cyclophosphamide | 2.5 | 10 | 210 | 318 | 1.514 | 31.80 | 25.5 | 271.656 | |
Trend: | -2.879 | ||||||||
Probability: | 0.998 |