Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02744-0002-0000-1 |
Chemical Name: | Propionitrile |
CASRN: | 107-12-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 522045_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Propionitrile | 265 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
882 | 200 | 4 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | ||
2650 | 138 | 2 | 0.014 | 1.4 | 0 | 0.000 | 0.0 | 1 | 0.007 | 0.7 | 1 | 0.007 | 1.0 | ||
4410 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 35 | 205 | 5.857 | 94.0 | 26 | 0.743 | 48.6 | 29 | 0.829 | 42.9 | 150 | 4.286 | 15.0 |
Mitomycin-C | 5 | 15 | 88 | 5.867 | 100.0 | 3 | 0.200 | 20.0 | 11 | 0.733 | 20.0 | 74 | 4.933 | 11.0 | |
Trend: | 0.411 | -1.209 | 0.821 | ||||||||||||
Probability: | 0.341 | 0.887 | 0.206 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Propionitrile | 441 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 |
1320 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
4410 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 35 | 0.700 | 44.0 | 9 | 0.180 | 18.0 | 24 | 0.480 | 32.0 | 2 | 0.040 | 1.0 |
Trend: | -2.551 | -1.893 | -1.780 | ||||||||||||
Probability: | 0.995 | 0.971 | 0.962 |