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Study Information
Study Attribute Value
CEBS Accession Number: 002-02744-0002-0000-1
Chemical Name: Propionitrile
CASRN: 107-12-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 522045_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/05/1986    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Propionitrile 
265         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
882         
 200 4 0.020 1.0 0 0.000 0.0 4 0.020 1.0 0 0.000 0.0 
2650         
 138 2 0.014 1.4 0 0.000 0.0 1 0.007 0.7 1 0.007 1.0 
4410         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 35 205 5.857 94.0 26 0.743 48.6 29 0.829 42.9 150 4.286 15.0
Mitomycin-C 
5         
 15 88 5.867 100.0 3 0.200 20.0 11 0.733 20.0 74 4.933 11.0
Trend: 0.411 -1.209 0.821  
Probability: 0.341 0.887 0.206  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/06/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Propionitrile 
441         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0 
1320         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
4410         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 35 0.700 44.0 9 0.180 18.0 24 0.480 32.0 2 0.040 1.0
Trend: -2.551 -1.893 -1.780  
Probability: 0.995 0.971 0.962