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Study Information
Study Attribute Value
CEBS Accession Number: 002-02745-0001-0000-1
Chemical Name: Propyl gallate
CASRN: 121-79-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 257022_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/16/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 427 0.407 8.54 26.5 0.000
Test Chemical Propyl gallate 
 0.5       
 50 1049 469 0.447 9.38 26.5 9.941 
1.6       
 50 1047 428 0.409 8.56 26.5 0.521 
5         
 50 1047 507 0.484 10.14 26.5 19.076 
16         
 16 337 311 0.923 19.44 26.5 126.930 
50         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 533 0.508 10.66 26.5 24.824
Mitomycin-C 
 0.005     
 10 206 201 0.976 20.10 26.5 139.933
Trend: 8.253        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/14/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 419 0.399 8.38 26.5 0.000
Test Chemical Propyl gallate 
3         
 50 1050 486 0.463 9.72 26.5 16.101 
5         
 50 1046 484 0.463 9.68 26.5 16.065 
7.5       
 50 1047 587 0.561 11.74 26.5 40.631 
10         
 36 755 614 0.813 17.06 26.5 103.991 
16         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 603 0.575 12.06 26.5 44.326
Mitomycin-C 
 0.005     
 10 210 260 1.238 26.00 26.5 210.558
Trend: 10.943        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 06/25/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 463 0.441 9.26 26.0 0.000
Test Chemical Propyl gallate 
3         
 50 1048 529 0.505 10.58 26.0 14.473 
5         
 50 1047 633 0.605 12.66 26.0 37.109 
7.5       
 50 1049 757 0.722 15.14 31.0 63.655 
10         
 50 1049 869 0.828 17.38 31.0 87.868 
16         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 652 0.623 13.04 26.0 41.359
Mitomycin-C 
 0.005     
 10 209 267 1.278 26.70 26.0 189.717
Trend: 12.793        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 488 0.464 9.76 26.5 0.000
Test Chemical Propyl gallate 
5         
 50 1049 459 0.438 9.18 26.5 -5.763 
16         
 50 1046 509 0.487 10.18 26.5 4.802 
50         
 50 1043 584 0.560 11.68 26.5 20.590 
160         
 50 1047 591 0.564 11.82 26.5 21.569 
500         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1048 1163 1.110 23.26 26.5 139.002
Cyclophosphamide 
 0.6       
 10 210 341 1.624 34.10 26.5 249.718
Trend: 4.655        
Probability: 0.000