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Study Information
Study Attribute Value
CEBS Accession Number: 002-02745-0002-0000-2
Chemical Name: Propyl gallate
CASRN: 121-79-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 257022_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 
No Activation  3  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 06/12/1985    Harvest Time: 22.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Propyl gallate 
5         
 200 48 0.240 7.0 14 0.070 3.0 14 0.070 5.0 20 0.100 2.0 
16         
 200 126 0.630 43.0 18 0.090 8.0 108 0.540 37.0 0 0.000 0.0 
30         
 45 54 1.200 49.0 9 0.200 18.0 45 1.000 40.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 135 0.675 45.0 68 0.340 27.0 67 0.335 29.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 70 1.400 66.0 31 0.620 46.0 29 0.580 38.0 10 0.200 1.0
Trend: 12.138 5.443 11.028  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/15/1985    Harvest Time: 19.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Propyl gallate 
300         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
400         
 200 8 0.040 4.0 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 5 0.025 3.0 3 0.015 2.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 378 1.890 81.0 168 0.840 53.0 169 0.845 57.0 41 0.205 5.0
Trend: 1.986 2.587 0.334  
Probability: 0.024 0.005 0.369  


Trial #:2   Activation: No Activation    Date: 05/15/1985    Harvest Time: 23.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Propyl gallate 
16         
 200 123 0.615 20.0 54 0.270 12.0 37 0.185 13.0 32 0.160 5.0 
30         
 200 192 0.960 50.0 27 0.135 11.0 145 0.725 46.0 20 0.100 2.0 
50         
 64 132 2.063 89.0 19 0.297 22.0 112 1.750 84.0 1 0.016 1.0 
75         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 178 0.890 53.0 99 0.495 32.0 69 0.345 30.0 10 0.050 1.0
Trend: 15.086 5.212 14.914  
Probability: 0.000 0.000 0.000  


Trial #:3   Activation: No Activation    Date: 07/24/1985    Harvest Time: 22.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Propyl gallate 
1         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0 
2.5       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5         
 200 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0 0 0.000 0.0 
16         
 200 218 1.090 55.0 32 0.160 12.0 146 0.730 49.0 4 0.020 4.0 
30         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 134 0.670 40.0 56 0.280 23.0 68 0.340 27.0 10 0.050 1.0
Mitomycin-C 
 0.125     
 50 85 1.700 68.0 40 0.800 50.0 45 0.900 52.0 0 0.000 0.0
Trend: 14.972 6.108 14.236  
Probability: 0.000 0.000 0.000