Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02745-0011-0000-2
Chemical Name: Propyl gallate
CASRN: 121-79-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 099874
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 80 99 149 62 66
    73 79 166 76
    91 91 204 75
    109 131 170 52
Test Chemical Propyl gallate 
62.5       
 72 15 1051 485 469*
    71 19 968 452
  
125         
 73 12 617 280 278*
    74 11 615 276
  
250         
 73 7 248 114 113*
    69 7 230 112
  
500         
 50 3 193 128 132*
    63 4 256 135
  
1000         
   
Positive Control Methyl Methane Sulfonate 
15         
 37 25 419 379 397*
    41 28 514 415
Methyl Methane Sulfonate 
250         
 70 79 453 217 235*
    56 79 420 252

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 82 95 114 46 38
    77 98 70 30
    85 101 85 34
    108 106 131 40
Test Chemical Propyl gallate 
50         
 75 16 518 231 210*
    80 17 456 190
  
100         
 70 11 262 125 136*
    67 13 297 147
  
200         
 70 7 203 97 100*
    56 7 171 102
  
300         
   
Positive Control Methyl Methane Sulfonate 
15         
 45 27 250 187 179*
    46 27 233 171
Methyl Methane Sulfonate 
250         
 77 64 354 154 158*
    71 60 346 162

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 65 109 108 55 60
    75 99 166 73
    75 97 103 46
    64 95 127 66
Test Chemical Propyl gallate 
 0.5       
 77 62 287 124 112*
    72 62 215 100
  
1         
 76 19 381 166 182*
    64 23 378 198
  
2         
 72 19 360 166 171*
    58 17 307 175
  
4         
 55 17 271 165 166*
    57 13 283 167
  
5         
 59 16 325 184 156*
    90 22 342 127
Positive Control Methyl Methane Sulfonate 
15         
 21 18 279 439 432*
    25 17 321 425

Nonactivation Trial: 4 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 72 111 122 56 51
    64 93 121 63
    86 105 102 40
    80 91 106 44
Test Chemical Propyl gallate 
25         
 54 17 698 431 425*
    65 20 810 419
  
50         
 42 16 685 542 508*
    51 18 727 475
  
75         
 63 16 813 428 438*
    48 11 640 448
  
100         
 45 11 690 517 455*
    60 12 711 393
  
125         
 60# 7 631 354 390*
    46 7 592 427
Positive Control Methyl Methane Sulfonate 
15         
 19 18 371 645 640*
    14 12 260 634

Nonactivation Trial: 5 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 78 99 168 72 65
    66 92 121 61
    49r 87 135 92
    82 109 153 62
Test Chemical Propyl gallate 
12.5       
 70 44 446 211 184*
    65 40 306 157
  
25         
 45 18 568 425
    82r 17 815 333
  
50         
 62 17 446 240 278*
    52 14 491 317
  
75         
 63 8 673 358 334*
    57 9 527 309
  
100         
 31 8 287 312 313*
    38 8 360 314
  
125         
   
Positive Control Methyl Methane Sulfonate 
15         
 21 11 256 406 426*
    26 12 347 445

Nonactivation Trial: 6 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 73 99 127 58 48
    99 110 114 38
    79# 86 117 50
    70 106 98 46
Test Chemical Propyl gallate 
12.5       
 83 18 625 251 249*
    73 17 542 247
  
25         
 93 14 284 102 108*
    91 15 312 115
  
50         
 52 8 226 146 138*
    54 9 210 131
  
75         
  
100         
   
Positive Control Methyl Methane Sulfonate 
15         
 23 25 288 411 383*
    27 26 285 354

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination