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Study Information
Study Attribute Value
CEBS Accession Number: 002-02747-0007-0000-9
Chemical Name: Propylene
CASRN: 115-07-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 537921
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 78 88 106 46 49
    94# 103 148 53
    83 101 114 46
    82 108 126 51
Test Chemical Propylene 
2.5       
 80 78 117 49 47
    83 86 112 45
  
5         
 83 90 91 36 44
    79 107 120 51
  
10         
 72 84 76 35 35
    69 99 73 35
  
20         
 83 93 73 29 30
    75 82 70 31
  
30         
 87 96 128 49 45
    84 85 102 41
Positive Control Methyl Methane Sulfonate 
15         
 28 13 340 407 395*
    24 19 272 383

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 93 98 43 15 23
    86 95 78 30
    75 112 76 34
    81 95 29 12
Test Chemical Propylene 
2.5       
 66 83 65 33 29
    87 93 65 25
  
5         
 65 76 44 23 21
    65 78 40 20
  
10         
 60 77 89 49 33
    64 81 33 17
  
20         
 61 84 52 28 30
    53 81 49 31
  
30         
 57 71 37 22 21
    60 77 36 20
Positive Control Methyl Methane Sulfonate 
15         
 19 14 137 240 222*
    24 11 146 203

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 91 117 47 17 25
    89 90 65 24
    94 98 79 28
    86 96 79 31
Test Chemical Propylene 
2.5       
 77 59 39 17 21
    83 88 63 25
  
5         
 80 92 43 18 19
    82 80 49 20
  
10         
 88 86 73 28 18
    73 89 20 9
  
20         
 86 85 76 29 27
    56 62 41 24
  
30         
 76 77 49 21 22
    71 79 49 23
Positive Control 3-Methylcholanthrene 
2.5       
 57 35 288 167 176*
    61 36 338 185

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Air 
 0         
 90 96 43 16 17
    70 88 33 16
    93 114 50 18
    78 102 47 20
Test Chemical Propylene 
2.5       
 81 85 80 33 28
    85 94 60 24
  
5         
 86 79 88 34 32*
    76 85 68 30
  
10         
 87 78 71 27 30*
    77 75 77 33
  
20         
 71 88 85 40 32*
    71 64 53 25
  
30         
 87 93 95 37 45*
    67 62 109 54
Positive Control 3-Methylcholanthrene 
2.5       
 105 117 66 21 19
    81 113 43 18

Induced S9 Trial: 3 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Air 
 0         
 69 106 37 18 21
    60 89 33 18
    70 103 54 26
    69 102 46 22
Test Chemical Propylene 
10         
 59 105 21 12 23
    57 91 58 34
  
20         
 68 106 75 37 39*
    73 113 89 41
  
30         
 51 91 37 24 27
    55 103 50 30
  
40         
 67 108 65 33 36*
    58 110 68 39
  
50         
 53 77 51 32 30
    73 118 63 29
Positive Control 3-Methylcholanthrene 
2.5       
 40 40 244 206 229*
    41 45 307 253

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination