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Study Information
Study Attribute Value
CEBS Accession Number: 002-02748-0001-0000-4
Chemical Name: Propylene glycol mono-t-butyl ether
CASRN: 57018-52-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 911469_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/07/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 362 0.345 7.24 26.0 -5.483
Dimethyl Sulfoxide 
0         
 50 1049 383 0.365 7.66 26.0 0.000
Test Chemical Propylene glycol mono-t-butyl ether 
167         
 50 1047 400 0.382 8.00 26.0 4.638 
500         
 50 1049 369 0.352 7.38 26.0 -3.655 
1667         
 50 1050 387 0.369 7.74 26.0 0.948 
5000         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 497 0.473 9.94 26.0 29.641
Mitomycin-C 
 0.004     
 10 210 217 1.033 21.70 26.0 183.020
Trend: -0.223        
Probability: 0.588        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/07/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 389 0.370 7.78 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 387 0.369 7.74 26.0 -0.419
Test Chemical Propylene glycol mono-t-butyl ether 
500         
 50 1050 387 0.369 7.74 26.0 -0.514 
1667         
 50 1051 381 0.363 7.62 26.0 -2.150 
5000         
 50 1049 392 0.374 7.84 26.0 0.867
Positive Control Cyclophosphamide 
 0.125     
 50 1049 498 0.475 9.96 26.0 28.143
Cyclophosphamide 
 0.5       
 10 210 180 0.857 18.00 26.0 131.362
Trend: 0.035        
Probability: 0.486