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Study Information
Study Attribute Value
CEBS Accession Number: 002-02755-0001-0000-2
Chemical Name: Pyrene
CASRN: 129-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 587427_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/26/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 318 0.304 6.36 25.8 0.000
Test Chemical Pyrene 
48         
 50 1049 325 0.310 6.50 25.8 2.006 
160         
 50 1049 361 0.344 7.22 25.8 13.306 
480         
 50 1048 430 0.410 8.60 25.8 35.091
Positive Control Mitomycin-C 
 0.001     
 50 1050 598 0.570 11.96 25.8 87.513
Mitomycin-C 
 0.01      
 5 105 192 1.829 38.40 25.8 502.049
Trend: 4.364        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/04/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 159 0.303 6.36 25.8 0.000
Test Chemical Pyrene 
320         
 25 524 172 0.328 6.88 25.8 8.383 
480         
 25 524 227 0.433 9.08 25.8 43.040 
640         
 25 525 249 0.474 9.96 25.8 56.604
Positive Control Mitomycin-C 
 0.001     
 25 525 308 0.587 12.32 25.8 93.711
Mitomycin-C 
 0.01      
 5 105 189 1.800 37.80 25.8 494.340
Trend: 5.153        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/26/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 356 0.339 7.12 25.8 0.000
Test Chemical Pyrene 
48         
 50 1050 505 0.481 10.10 25.8 41.854 
160         
 50 1050 532 0.507 10.64 25.8 49.438 
480         
 50 1047 578 0.552 11.56 25.8 62.825
Positive Control Cyclophosphamide 
 0.4       
 50 1049 582 0.555 11.64 25.8 63.639
Cyclophosphamide 
2         
 5 105 161 1.533 32.20 25.8 352.247
Trend: 7.028        
Probability: 0.000