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Study Information
Study Attribute Value
CEBS Accession Number: 002-02755-0006-0000-7
Chemical Name: Pyrene
CASRN: 129-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A72952_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/11/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0208
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical Pyrene 
500         
 8 0.25 ± 0.25 0.5000
  
1000         
 8 0.75 ± 0.53 0.1580
  
2000         
 8 1.25 ± 0.53 0.0506
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/15/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0437
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 35.00 ± 2.20 0.0000
Test Chemical Pyrene 
200         
 8 1.00 ± 0.53 0.9190
  
400         
 8 2.25 ± 0.88 0.5000
  
800         
 8 3.50 ± 1.84 0.1451
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.70 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/04/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2573
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.25 ± 2.75 0.0000
Test Chemical Pyrene 
1500         
 8 2.00 ± 0.65 0.0281
  
2000         
 8 0.75 ± 0.37 0.3269
  
2500         
 8 1.00 ± 0.53 0.2062
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed