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Study Information
Study Attribute Value
CEBS Accession Number: 002-02756-0001-0000-3
Chemical Name: Pyridine
CASRN: 110-86-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 148320_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/06/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 424 0.404 8.48 31.0 0.000
Water 
0         
 50 1049 415 0.396 8.30 26.0 -2.123
Test Chemical Pyridine 
167         
 50 1043 407 0.390 8.14 26.0 -3.457 
502         
 50 1049 437 0.417 8.74 26.0 3.066 
1673         
 50 1050 434 0.413 8.68 31.0 2.261 
5020         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 665 0.634 13.30 26.0 56.840
Mitomycin-C 
 0.004     
 10 208 201 0.966 20.10 26.0 139.080
Trend: 0.604        
Probability: 0.273        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/06/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 389 0.370 7.78 26.0 0.000
Test Chemical Pyridine 
502         
 50 1048 416 0.397 8.32 26.0 7.145 
1673         
 50 1051 421 0.401 8.42 26.0 8.123 
5020         
 50 1051 388 0.369 7.76 26.0 -0.352
Positive Control Cyclophosphamide 
 0.125     
 50 1051 598 0.569 11.96 26.0 53.581
Cyclophosphamide 
 0.5       
 10 207 186 0.899 18.60 26.0 142.539
Trend: 0.014        
Probability: 0.494