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Study Information
Study Attribute Value
CEBS Accession Number: 002-02756-0004-0000-6
Chemical Name: Pyridine
CASRN: 110-86-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 631306_CA
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #:1   Activation: No Activation    Date: 10/04/1983    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Pyridine 
2930         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
3260         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
3590         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.04      
 25 27 1.080 64.0 14 0.560 48.0 13 0.520 44.0 0 0.000 0.0
Trend: 1.209 0.479 0.016  
Probability: 0.113 0.316 0.494  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/04/1983    Harvest Time: 10.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Pyridine 
7500         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
8150         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
8800         
 100 35 0.350 32.0 2 0.020 2.0 33 0.330 33.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
75         
 50 16 0.320 22.0 7 0.140 12.0 9 0.180 12.0 0 0.000 0.0
Trend: 7.410 1.832 7.754  
Probability: 0.000 0.033 0.000