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Study Information
Study Attribute Value
CEBS Accession Number: 002-02756-0029-0000-3
Chemical Name: Pyridine
CASRN: 110-86-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A86776_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/24/93 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2224
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 2.25 ± 0.45 0.0168
  
2         
 8 9.50 ± 1.76 0.0000
Test Chemical Pyridine 
400         
 8 0.50 ± 0.50 0.5000
  
500         
 8 1.75 ± 0.59 0.0469
  
600         
 8 0.50 ± 0.33 0.5000
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/22/94 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.9477
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 3.00 ± 0.85 0.0763
  
2         
 8 6.25 ± 2.31 0.0003
Test Chemical Pyridine 
400         
 8 0.75 ± 0.53 0.8427
  
500         
 8 1.50 ± 0.82 0.5000
  
600         
 8 0.00 ± 0.00 0.9930
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.63 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed