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Study Information
Study Attribute Value
CEBS Accession Number: 002-02758-0005-0000-9
Chemical Name: Pyrilamine maleate
CASRN: 59-33-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A32244_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/18/92 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6478
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 5.00 ± 1.81 0.0002
Test Chemical Pyrilamine maleate 
20         
 8 1.25 ± 0.84 0.2386
  
40         
 8 0.00 ± 0.00 0.9587
  
60         
 8 0.75 ± 0.53 0.5000
  
80         
 8 0.75 ± 0.37 0.5000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/09/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3077
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 1.75 ± 0.45 0.1015
  
2         
 8 3.00 ± 0.85 0.0095
Test Chemical Pyrilamine maleate 
20         
 8 1.00 ± 0.38 0.3521
  
40         
 8 0.50 ± 0.33 0.6731
  
60         
 8 1.25 ± 0.75 0.2386
  
80         
 8 1.00 ± 0.53 0.3521
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed